robustness definition in analytical chemistry

Robustness and ruggedness are frequently confused and interrelated. Critical Reviews in Analytical Chemistry: Vol. (2006). Examples of typical variations are : Stability of analytical solutions. Method validation is a key element in the establishment of reference methods and within the assessment of a laboratory’s competence in generating dependable analytical records. 221-242. Robustness It is the reliability of an analysis with respect to deliberate variations in method parameters. Temperature. 44 Analytical Chemistry 2.0 Finally, a protocol is a set of stringent guidelines specifying a proce-dure that must be followed if an agency is to accept the results. Robustness and Outlier Detection in Chemometrics. Validation has been placed within the context of the procedure, generating chemical data. Robustness The robustness of an analytical procedure is a measure of its capacity to remain unaffected by small, but deliberate, variations in method parameters and provides an indication of its reliability during normal usage. Chapter 3 REVIEW OF THE USE OF ROBUSTNESS AND RUGGEDNESS IN ANALYTICAL CHEMISTRY Y. VANDER HEYDEN AND D.L. Robustness testing deals with the critical operational parameters and the tolerances for their control. Robustness is the property of being strong and healthy in constitution. Also see: Analytical Method Validation A third definition proposes that this analytical parameter is “the capacity of an analytical procedure to remain unaffected by small but deliberately introduced variations in method parameters and provides an indication of its reliability during normal usage” . pH of mobile phase. It also calls for theoretical studies to predict robustness of these chemistries and, more generally, to design robust reaction architectures. different column makes. developed, but their robustness is not well understood. This work implies that these chemistries may be significantly more robust in the digital, rather than kinetic, format. Note: Ideally, robustness should be explored during the development of the assay method. Flow rate. ... accuracy, precision, sensitivity, selectivity, robustness, ruggedness, scale of operation, analysis time, availability of equipment, and cost. 36, No. Definition Analytical Chemistry can be defined in four simple ways as: (1) the discipline in charge of “Analysis” (the fourth component of Chemistry in addition to Theory, Synthesis and ... 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